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Glenn Wolkenfeld
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Glycolysis!
Hey Sugar Common over here sweetie Let's break it down Glycolysis, is a series of reactions, enzymatic actions, energy transactions. Takes glucose, a molecule so sugary, breaks it down for NADH and ATP. It's an anaerobic cytoplasmatic pathway that amazes, Organized easily into three phases Investment, cleavage, and energy harvest Tell me later which one you like best Investment: activation energy's supplied Cleavage: our six carbon sugar divides Harvest: we get our energy yeild So beautiful, so intricate, Keep your eyes peeled Glycolysis! Come on sugar, Come on sugar, for the breakdown, For the breakdown. Investment's like striking a match That energy you put in makes the fire catch For glycolysis investment's two ATPs which act as activation energy. Enzymes take phosphates from ATPs Jam 'em onto glucose rearranging it to fructose Leaving fructose 1-6 biphosphate on the table With two phosphates, it's highly unstable Moving us to the second phase, the cleaving of fructose biphosphate. 'Cause glycolysis means 'splitting sugar' you can see Cleavage yeilds two molecules with carbons three One is glyceraldehyde 3-phosphate, G3P It continues on our pathway broken down for energy But the second one an enzyme will immediately Convert into a second G3P Glycolysis! Come on sugar, Come on sugar, for the breakdown, For the breakdown. Phase 3: G3P gets rearranged and oxidized By an enzymatic assembly line That harvests energy from each G3P, one NADH and two ATPs Double this yeild per G3P to two NADH and 4 ATPs Find more lyrics at ※ Mojim.com That's a gross yeild for every glucose in A generous accounting of glycolysis's win But two ATPs were invested in phase one So you net just two you can use to jump or run Put two in, get four out, your net gain is two Two ATPs that you can use If that doesn't seem like very much it's 'cause it ain't There's tons of energy left in pyruvate The two 3-carbon molecules we're left with at the end And what happens to pyruvate's gonna have to depend On the metabolic pathway where pyruvate gets sent If it's anaerobic it'll be fermented But in aerobic cells, pyruvate's termination will be the Krebs cycle and total oxidation Glycolysis! Come on sugar, Come on sugar, for the breakdown, For the breakdown. Glycolysis starts with investment Of two ATPs to the glucose that we started with The product is cleaved into two G3Ps From which the cell harvests NADH and ATPs This anaerobic pathway is is respiration's first phase Billions of years old evolved in ancient days Before O2 accumulated in the seas Before eukaryotic cells arrived on the scene It's everywhere, ubiquitous, in every organism Bacteria, sequoia tree No matter your metabolism Happens in the cytoplasm doesn't need no organelles You want to find glycolysis? Look in any cell! Glycolysis! Come on sugar, Come on sugar, for the breakdown, For the breakdown! Glycolysis! Come on sugar, Come on sugar, for the breakdown, For the breakdown!
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